Lee S-W, Park M-C, Kim H, Park Y-B, Lee S-K
Division of Rheumatology, Department of Internal Medicine, Institute for Immunology and Immunological Disease, BK21 Project for Medical science, Yonsei University College of Medicine, Shinchon-dong, Seoul, Korea.
Clin Exp Rheumatol. 2007 Mar-Apr;25(2):312-4.
Adult onset Still's disease (AOSD) is a systemic inflammatory disorder of unknown cause characterized by high fever accompanied by systemic manifestations. Since AOSD consists of heterogeneous symptoms and has no definite diagnostic tool, the diagnosis is based upon exclusive criteria. Dermatopathic lymphadenopathy (DL) is characterized by a localized paracortical proliferation of histiocytes and deposition of melanin in the lymph nodes. DL is not only a reactive hyperplasia of the lymph nodes, but has also been reported to be associated with hematological malignancies such as cutaneous T cell lymphoma (CTCL) and Hodgkin's lymphoma. It is therefore important to evaluate CTCL or Hodgkin's lymphoma in a patient with DL, in order to both rule out hematological malignancy and diagnose AOSD. In this report, we first describe a 37-year-old patient with AOSD whose biopsy of lymph node was proved to be DL.
成人斯蒂尔病（AOSD）是一种病因不明的全身性炎症性疾病，其特征为高热并伴有全身症状。由于AOSD症状多样且没有明确的诊断工具，其诊断基于排他性标准。皮肤型淋巴结病（DL）的特征是淋巴结内组织细胞局限性副皮质增生和黑色素沉积。DL不仅是淋巴结的反应性增生，而且据报道还与血液系统恶性肿瘤如皮肤T细胞淋巴瘤（CTCL）和霍奇金淋巴瘤有关。因此，对于DL患者评估CTCL或霍奇金淋巴瘤很重要，以便既排除血液系统恶性肿瘤又诊断AOSD。在本报告中，我们首先描述一名37岁的AOSD患者，其淋巴结活检证实为DL。
