一种来自刚果厚皮丹（Pachypodanthium confine Engl. and Diels）的生物碱、两种共轭倍半萜和一种苯丙素类化合物。

An alkaloid, two conjugate sesquiterpenes and a phenylpropanoid from Pachypodanthium confine Engl. and Diels.

作者信息

Mathouet Hilarion, Elomri Abdelhakim, Lameiras Pedro, Daïch Adam, Vérité Philippe

机构信息

Laboratoire de Pharmacognosie, UMR 6014-CNRS, Université de Rouen, Faculté de Pharmacie, 22 Boulevard Gambetta, F-76183 Rouen Cedex 1, France.

出版信息

Phytochemistry. 2007 Jul;68(13):1813-8. doi: 10.1016/j.phytochem.2007.04.001. Epub 2007 Jun 1.

DOI:10.1016/j.phytochem.2007.04.001

PMID:17544038

Abstract

Two sesquiterpene-trimethoxystyrene conjugates (E)-1-[3'-(4'',8''-dimethylnona-3'',7''-dienyl)cyclohex-3'-enyl]-2,4,5-trimethoxybenzene (1) and (Z)-1-[3'-(4'',8''-dimethylnona-3'',7''-dienyl)cyclohex-3'-enyl]-2,4,5-trimethoxybenzene (2), a phenylpropanoid 1,2,4-trimethoxy-5-(1-methoxy-ethyl)-benzene (3), and an aporphine alkaloid N-acetylpachypodanthine (4), were isolated in addition to several known compounds from cyclohexane, dichloromethane and alkaloid extracts from bark of Pachypodanthium confine. The structures of these compounds were established based on the interpretation of their high resolution NMR (HSQC, HMBC, COSY and NOESY) spectral data.

摘要

除了从围柱树（Pachypodanthium confine）树皮的环己烷、二氯甲烷和生物碱提取物中分离出几种已知化合物外，还分离出了两种倍半萜-三甲氧基苯共轭物（E）-1-[3'-(4'',8''-二甲基壬-3'',7''-二烯基)环己-3'-烯基]-2,4,5-三甲氧基苯（1）和（Z）-1-[3'-(4'',8''-二甲基壬-3'',7''-二烯基)环己-3'-烯基]-2,4,5-三甲氧基苯（2）、一种苯丙素类化合物1,2,4-三甲氧基-5-(1-甲氧基乙基)苯（3）以及一种阿朴啡生物碱N-乙酰基围柱树碱（4）。这些化合物的结构是根据其高分辨率核磁共振（HSQC、HMBC、COSY和NOESY）光谱数据的解析确定的。