从清香木属植物中提取的抗生素吲哚倍半萜生物碱，具有全新的天然产物骨架。

Antibiotic indole sesquiterpene alkaloid from Greenwayodendron suaveolens with a new natural product framework.

机构信息

Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., 1912 Innerbelt Business Center Drive, St. Louis, Missouri 63114, USA.

出版信息

J Nat Prod. 2010 May 28;73(5):1008-11. doi: 10.1021/np1001225.

DOI:10.1021/np1001225

PMID:20405845

Abstract

High-throughput natural products chemistry methods have led to the isolation of three new (1-3) and two known indole sesquiterpene alkaloids (4, 5) from Greenwayodendron suaveolens. Their structures were determined using CapNMR and MS. Pentacyclindole (1) was determined to possess a new natural product framework. Pentacyclindole (1) and polyalthenol (4) showed activity against clinical isolates of Staphylococcus aureus with polyalthenol (4) demonstrating a MIC(90) of 4 microg/mL.

摘要

高通量天然产物化学方法已从绿楠中分离得到三种新的（1-3）和两种已知的吲哚倍半萜生物碱（4,5）。它们的结构通过 CapNMR 和 MS 确定。戊环吲哚（1）被确定具有新的天然产物骨架。戊环吲哚（1）和多醇（4）对金黄色葡萄球菌的临床分离株表现出活性，其中多醇（4）的 MIC（90）为 4 μg/mL。