Smout André J P M
Department of Gastroenterology, University Medical Center, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.
Best Pract Res Clin Gastroenterol. 2007;21(3):365-78. doi: 10.1016/j.bpg.2007.01.007.
Treatment of gastro-oesophageal reflux disease (GORD) by means of gastric acid secretion inhibition usually is successful. When symptoms persist despite adequate treatment, correctness of the diagnosis of GORD should be questioned. Quite often dyspeptic symptoms are erroneously interpreted as GORD symptoms. Other causes of treatment failure are insufficient acid suppression and oesophageal hypersensitivity. In the management of patients with persistent symptoms oesophageal pH and impedance monitoring are useful techniques. These may provide answers to the question whether the symptoms are reflux-related and whether acid secretion is adequately suppressed.
通过抑制胃酸分泌来治疗胃食管反流病（GORD）通常是成功的。如果在充分治疗后症状仍持续存在，就应该质疑GORD诊断的正确性。消化不良症状常常被错误地解释为GORD症状。治疗失败的其他原因包括胃酸抑制不足和食管超敏反应。对于症状持续的患者，食管pH监测和阻抗监测是有用的技术。这些技术可以回答症状是否与反流相关以及胃酸分泌是否得到充分抑制的问题。
