Yoon Yoosik, Park Byung Lae, Cha Min Ho, Kim Kil Soo, Cheong Hyun Sub, Choi Yoo Hyun, Shin Hyoung Doo
Department of Microbiology, Medical School, Chung-Ang University, Seoul 156-756, Republic of Korea.
Biochem Biophys Res Commun. 2007 Aug 3;359(3):451-6. doi: 10.1016/j.bbrc.2007.05.110. Epub 2007 May 25.
The uncoupling protein (UCP) family has been suggested as a possible determinant affecting obesity risk given their function in the regulation of energy metabolism. In an effort to elucidate the effects of UCP family polymorphisms on obesity phenotypes, we genotyped 10 polymorphisms in UCP2 and UCP3 among overweight female subjects (n=458), and genetic effects on BMI and changes after a very low calorie diet (VLCD) were examined. Analyses of VLCD-induced changes among the subjects who had finished one month-weight control program (n=301) revealed that several polymorphisms in UCP2-3 gene cluster showed associations with changes of BMI and fat mass, however not of protein mass. One of the major haplotypes of UCP2-3 gene cluster, ht1 (GGCdelCGTACC), and UCP2-866G>A showed significant associations with VLCD-induced fat reduction (P=0.002 and 0.004; P(corr)=0.03 and 0.01, respectively), and these results suggested that UCP2-3 polymorphisms were important genetic factor for the VLCD-induced reduction of body fat mass.
鉴于解偶联蛋白（UCP）家族在能量代谢调节中的作用，它们被认为是影响肥胖风险的一个可能决定因素。为了阐明UCP家族多态性对肥胖表型的影响，我们对458名超重女性受试者的UCP2和UCP3基因中的10个多态性进行了基因分型，并研究了其对体重指数（BMI）以及极低热量饮食（VLCD）后变化的遗传效应。对完成了一个月体重控制计划的301名受试者中VLCD诱导变化的分析显示，UCP2 - 3基因簇中的几个多态性与BMI和脂肪量的变化相关，但与蛋白质量无关。UCP2 - 3基因簇的主要单倍型之一ht1（GGCdelCGTACC）以及UCP2 - 866G>A与VLCD诱导的脂肪减少显著相关（P = 0.002和0.004；校正P值分别为0.03和0.01），这些结果表明UCP2 - 3多态性是VLCD诱导身体脂肪量减少的重要遗传因素。
