Dresch C
Sem Hop. 1975 Feb 26;51(10):653-8.
Polymorphonuclear leukocytosis and granulopenia in infectious diseases have been studied for several years, either by intravascular kinetics of the polymorphs labelled previously in vitro, or by isotopic labelling in vivo and autoradiography of the bone marrow, using medullary kinetic study of granulopoiesis. Polymorpho-nuclear leukocytosis is usually due to an increased production and a relative mobilisation of reserves. Leukopenia may be due to various mechanisms, but there does not seem to be any qualitative disorder of circulating polymorphonuclear leukocytes with corpuscular hyperdestruction nor any abnormalities of multiplication of the bone marrow nor of maturation. On the other hand, one frequently finds abnormalities of distribution between the marginal and circulating compartments, increased extracorpuscular destruction, reduction in production due to reduction in absolute number or differentiation of the granulopoietic parent cells.
关于传染病中多形核白细胞增多和粒细胞减少的情况，已经研究了数年，研究方法要么是对先前在体外标记的多形核细胞进行血管内动力学研究，要么是进行体内同位素标记以及骨髓放射自显影，并利用粒细胞生成的骨髓动力学研究。多形核白细胞增多通常是由于生成增加和储备的相对动员。白细胞减少可能由多种机制引起，但循环中的多形核白细胞似乎不存在伴有细胞过度破坏的定性紊乱，骨髓增殖或成熟也没有任何异常。另一方面，人们经常发现边缘池和循环池之间的分布异常、细胞外破坏增加、由于粒细胞生成祖细胞的绝对数量减少或分化导致的生成减少。
