McCormack M J, Mackenzie W E, Rushton D I, Newton J R
Academic Department of Obstetrics and Gynaecology, Birmingham Maternity Hospital, U.K.
Prenat Diagn. 1991 Nov;11(11):841-6. doi: 10.1002/pd.1970111105.
Twenty-nine cases of spontaneous abortion following first-trimester chorionic villus sampling (CVS) were reviewed out of a series of 722 patients. Of the 29 cases, there were only four abnormal CVS results. Pathological examination was performed in 79 per cent of cases, and this did not identify any characteristic pathological feature associated with spontaneous abortion after CVS. There was no obvious difference in the pathological features following the transabdominal (TA) or the transcervical (TC) methods. The majority of miscarriages occurred within 4 weeks of the procedure, but 38 per cent of cases aborted between 7 and 14 weeks after CVS. The TC method was used in 22 patients; the TA in 6; and both methods in 1 patient. The TA method was associated with a significantly lower fetal loss rate than the TC method (TA 2 per cent, TC 9 per cent, p less than 0.001).
在722例患者中，对29例孕早期绒毛取样（CVS）后自然流产的病例进行了回顾。在这29例病例中，只有4例CVS结果异常。79%的病例进行了病理检查，但未发现与CVS后自然流产相关的任何特征性病理特征。经腹（TA）或经宫颈（TC）方法后的病理特征无明显差异。大多数流产发生在手术后4周内，但38%的病例在CVS后7至14周流产。22例患者采用TC方法；6例采用TA方法；1例同时采用两种方法。TA方法的胎儿丢失率明显低于TC方法（TA为2%，TC为9%，p<0.001）。
