Jahoda M G, Brandenburg H, Reuss A, Cohen-Overbeek T E, Wladimiroff J W, Los F J, Sachs E S
Department of Obstetrics and Gynaecology, University Hospital Dijkzigt, Rotterdam, The Netherlands.
Prenat Diagn. 1991 Aug;11(8):559-61. doi: 10.1002/pd.1970110811.
Data from 3611 consecutive CVS (TC, N = 1780; TA, N = 1831) were analysed with emphasis put on influence of maternal and gestational age at CVS on the fetal loss rate less than 28 weeks. For TC-CVS the gestational age varied from 9.3-11.6 weeks, for TA-CVS from 9.3-20 weeks. Sampling efficacy at first attempt was 86.5 per cent and 95 per cent respectively. In 4.6 per cent an abnormal result was established. In older mothers (N = 2362) the fetal loss rate was significantly higher (p = less than 0.05) when sampled before 12 weeks (TC-CVS 6.2 per cent, TA-CVS 5.8 per cent). When the CVS (TA) was performed after 12 weeks the fetal loss rate decreased to 2.4 per cent. In 1079 younger women the fetal loss rate remained low (TC 2.8 per cent; TA less than 12 weeks 1.8 per cent; TA greater than 12 weeks 1.7 per cent) and was not influenced by gestational age at the time of sampling. We concluded both methods safe and reliable when the choice of application considers maternal age.
对3611例连续绒毛取样术（经宫颈绒毛取样术，n = 1780；经腹绒毛取样术，n = 1831）的数据进行了分析，重点关注绒毛取样术时的母亲年龄和孕周对小于28周胎儿丢失率的影响。经宫颈绒毛取样术的孕周为9.3 - 11.6周，经腹绒毛取样术的孕周为9.3 - 20周。首次尝试取样的成功率分别为86.5%和95%。4.6%的结果异常。在年龄较大的母亲（n = 2362）中，12周前取样时胎儿丢失率显著更高（p < 0.05）（经宫颈绒毛取样术为6.2%，经腹绒毛取样术为5.8%）。当经腹绒毛取样术在12周后进行时，胎儿丢失率降至2.4%。在1079名年轻女性中，胎儿丢失率仍然较低（经宫颈绒毛取样术为2.8%；经腹绒毛取样术在12周前为1.8%；经腹绒毛取样术在12周后为1.7%），且不受取样时孕周的影响。我们得出结论，当应用方法的选择考虑母亲年龄时，两种方法都是安全可靠的。
