Mayorga-Fayad Isabel, Lafaurie Gloria I, Contreras Adolfo, Castillo Diana M, Barón Alexandra, Aya María del Rosario
Laboratorio de Microbiología Oral, Instituto Unidad de Investigación Básica Oral, Universidad El Bosque, Bogotá, D.C, Colombia.
Biomedica. 2007 Mar;27(1):21-33. Epub 2007 May 31.
Periodontitis-associated microbiotas differ in regions around the world and vary with a variety of factors. This suggests that each country must establish its own dental microbiobiotic profile in order to formulate adequate prevention measures and more specific treatments.
The prevalence and proportions of the following microorganisms were investigated: Porphyromonas gingivalis, Tannerella forsythia, Actinobacillus actinomycetemcomitans, Prevotella intermedia/Prevotella nigrescens, Eikenella corrodens, Campylobacter rectus, Micromonas micros, Fusobacterium spp, Dialister pneumosintes and enteric rods. The patients selected had been diagnosed with chronic periodontitis and aggressive periodontitis from clinical populations in Bogotá, Colombia. The variables of age, gender and socioeconomic level were included in the comparisons.
183 patients were classified in two groups, chronic periodontitis (n=84) and aggressive periodontitis (n=59); 40 healthy subjects were selected for comparison. A pooled subgingival plaque sample was obtained from the 6 deepest periodontal pockets in every patient and processed by culture for the isolation and identification of bacteria.
In chronic periodontitis and aggressive periodontitis, P. gingivalis, T. forsythia, P. intermedia/P. nigrescens, C. rectus, Fusobacterium spp and E. corrodens showed high and similar prevalence, whereas M. micros, A. actinomycetemcomitans, D. pneumosintes and enteric rods (commonly from the tribe Klebsielleae) showed less and similar prevalence. In the healthy group, P. intermedia/P. nigrescens, C. rectus and Fusobacterium spp showed high frequency whereas M. micros and E. corrodens showed moderate frequency.
Porphyromonas gingivalis, T. forsythia, P. intermedia/P. nigrescens, C. rectus, Fusobacterium spp. and E. corrodens are important constituents of the microbiologic profile of the periodontitis in Colombian populations. Porphyromonas gingivalis was found more frequently than A. actinomycetemcomitans in aggressive periodontitis.
与牙周炎相关的微生物群在世界各地的不同地区存在差异，并且会因多种因素而有所变化。这表明每个国家都必须建立自己的口腔微生物图谱，以便制定适当的预防措施和更具针对性的治疗方法。
研究以下微生物的患病率和比例：牙龈卟啉单胞菌、福赛坦氏菌、伴放线放线杆菌、中间普氏菌/变黑普氏菌、腐蚀埃肯菌、直肠弯曲菌、微小单胞菌、梭杆菌属、嗜肺 Dialister 和肠道杆菌。所选患者来自哥伦比亚波哥大的临床人群，已被诊断患有慢性牙周炎和侵袭性牙周炎。比较中纳入了年龄、性别和社会经济水平等变量。
183 名患者分为两组，慢性牙周炎组（n = 84）和侵袭性牙周炎组（n = 59）；选取 40 名健康受试者作为对照。从每位患者的 6 个最深牙周袋中获取龈下菌斑混合样本，通过培养进行处理以分离和鉴定细菌。
在慢性牙周炎和侵袭性牙周炎中，牙龈卟啉单胞菌、福赛坦氏菌、中间普氏菌/变黑普氏菌、直肠弯曲菌、梭杆菌属和腐蚀埃肯菌的患病率较高且相似，而微小单胞菌、伴放线放线杆菌、嗜肺 Dialister 和肠道杆菌（通常来自克雷伯菌族）的患病率较低且相似。在健康组中，中间普氏菌/变黑普氏菌、直肠弯曲菌和梭杆菌属的出现频率较高，而微小单胞菌和腐蚀埃肯菌的出现频率中等。
牙龈卟啉单胞菌、福赛坦氏菌、中间普氏菌/变黑普氏菌、直肠弯曲菌、梭杆菌属和腐蚀埃肯菌是哥伦比亚人群牙周炎微生物图谱的重要组成部分。在侵袭性牙周炎中，牙龈卟啉单胞菌的检出频率高于伴放线放线杆菌。
