Lafaurie Gloria Inés, Contreras Adolfo, Barón Alexandra, Botero Javier, Mayorga-Fayad Isabel, Jaramillo Adriana, Giraldo Astrid, González Ferney, Mantilla Sergio, Botero Alejandro, Archila Luz Helena, Díaz Antonio, Chacón Tatiana, Castillo Diana Marcela, Betancourt Marisol, Del Rosario Aya Maria, Arce Roger
Basic Oral Research Unit Institute, El Bosque University, Bogotá, Colombia.
J Periodontol. 2007 Apr;78(4):629-39. doi: 10.1902/jop.2007.060187.
The microbial profile of periodontal disease varies among different human populations. This study evaluated the demographic, clinical, and microbiologic aspects of periodontitis in a multigeographic sample in Colombia.
Three hundred twenty-five patients with chronic periodontitis (CP), 158 patients with aggressive periodontitis (AgP), and 137 healthy-gingivitis controls from five regions of the country were studied. Clinical, microbial, and sociodemographic data were collected. Microbiologic identification was performed using polymerase chain reaction 16S rRNA gene on pooled subgingival samples, and the presence of Gram-negative enteric rods was evaluated by culture. Bivariate and multivariate logistic regression analyses were conducted.
Porphyromonas gingivalis occurred in 71.5% of individuals with periodontitis, Tannerella forsythensis occurred in 58.5%, Campylobacter rectus occurred in 57.5%, Actinobacillus actinomycetemcomitans occurred in 23.6%, and enteric rods occurred in 34.5%. P. gingivalis was more common in CP and AgP than controls. A. actinomycetemcomitans was increased in AgP compared to controls and patients with CP. T. forsythensis, C. rectus, and Eikenella corrodens had a low presence in the West Pacific and Central regions, and enteric rods were increased in the Central region (P <0.05). Other sociodemographic factors were not associated with these microorganisms.
Geographic regions do not influence the microbiota, but the microbiota may vary by geographic region. P. gingivalis, T. forsythensis, and C. rectus are the most prevalent periodontophatic microorganisms in Colombia. A. actinomycetemcomitans was more common in AgP, and a large percentage of the population studied had enteric rods in the subgingival plaque.
牙周病的微生物谱在不同人群中有所不同。本研究评估了哥伦比亚多地区样本中牙周炎的人口统计学、临床和微生物学特征。
对来自该国五个地区的325例慢性牙周炎（CP）患者、158例侵袭性牙周炎（AgP）患者和137例健康牙龈炎对照者进行了研究。收集了临床、微生物学和社会人口统计学数据。使用聚合酶链反应对龈下混合样本进行16S rRNA基因微生物鉴定，并通过培养评估革兰氏阴性肠道杆菌的存在情况。进行了双变量和多变量逻辑回归分析。
牙龈卟啉单胞菌在71.5%的牙周炎患者中出现，福赛坦氏菌在58.5%的患者中出现，直肠弯曲菌在57.5%的患者中出现，伴放线放线杆菌在23.6%的患者中出现，肠道杆菌在34.5%的患者中出现。牙龈卟啉单胞菌在CP和AgP患者中比对照组更常见。与对照组和CP患者相比，AgP患者中伴放线放线杆菌增多。福赛坦氏菌、直肠弯曲菌和腐蚀埃肯菌在西太平洋和中部地区的出现率较低，中部地区肠道杆菌增多（P<0.05）。其他社会人口统计学因素与这些微生物无关。
地理区域不影响微生物群，但微生物群可能因地理区域而异。牙龈卟啉单胞菌、福赛坦氏菌和直肠弯曲菌是哥伦比亚最常见的牙周致病微生物。伴放线放线杆菌在AgP中更常见，且研究人群中有很大比例的龈下菌斑中存在肠道杆菌。
