Gadi Ramprasad, Samaha Frederick F
Curr Diab Rep. 2007 Jun;7(3):228-34. doi: 10.1007/s11892-007-0036-0.
Cardiovascular disease is a significant cause of morbidity and mortality in patients with diabetes mellitus (DM). DM is now recognized as a risk equivalent for coronary heart disease. The lipid profile in patients with type 2 DM is characterized by elevated triglycerides, low levels of high-density lipoprotein cholesterol, and small dense low-density lipoprotein cholesterol (LDLC) particles and is believed to be a key factor promoting atherosclerosis in these patients. Both primary and secondary prevention studies have provided ample evidence that aggressive statin therapy reduces cardiovascular end points in patients with DM. In all persons with DM, current treatment guidelines recommend reduction of LDLC to less than 100 mg/dL, regardless of baseline lipid levels. Lowering LDLC to less than 70 mg/dL may provide even greater benefits, particularly in very high risk patients with DM and coronary heart disease.
心血管疾病是糖尿病（DM）患者发病和死亡的重要原因。DM目前被认为是冠心病的风险等同因素。2型DM患者的血脂谱特征为甘油三酯升高、高密度脂蛋白胆固醇水平低以及小而密的低密度脂蛋白胆固醇（LDLC）颗粒，被认为是促进这些患者动脉粥样硬化的关键因素。一级和二级预防研究均提供了充分证据，表明积极的他汀类药物治疗可降低DM患者的心血管终点事件。在所有DM患者中，当前的治疗指南建议将LDLC降至低于100mg/dL，无论基线血脂水平如何。将LDLC降至低于70mg/dL可能会带来更大益处，尤其是在患有DM和冠心病的极高风险患者中。
