Graffner H, Ekelund M, Håkanson R
Dept. of Surgery, University of Lund, Sweden.
Scand J Gastroenterol. 1991 Nov;26(11):1200-4. doi: 10.3109/00365529108998614.
Anaesthetized animals are often used in studies of gastric secretion. We have examined the effect of anaesthetics on the acid output in gastric fistula rats and pylorus-ligated rats, both vagally intact and denervated. Diethyl ether, chloral hydrate, and mebumal effectively reduced both basal and stimulated acid output in fistula rats. The acid output in pylorus-ligated rats was greatly reduced by the anaesthetics. In vagally denervated rats local nervous reflexes are thought to play an important role in the acid secretory response to pylorus ligation. Anaesthetic drugs suppressed acid output in both vagally intact and vagally denervated rats. The possibility of an action on intramural neurons cannot be excluded. The neuro-suppressive effect of anaesthesia should be considered in studies of gastric acid secretion.
麻醉动物常用于胃液分泌研究。我们研究了麻醉剂对胃瘘大鼠和幽门结扎大鼠胃酸分泌的影响，这些大鼠既有迷走神经完整的，也有迷走神经切断的。乙醚、水合氯醛和美索巴莫能有效降低胃瘘大鼠的基础胃酸分泌和刺激胃酸分泌。麻醉剂使幽门结扎大鼠的胃酸分泌大幅减少。在迷走神经切断的大鼠中，局部神经反射被认为在对幽门结扎的胃酸分泌反应中起重要作用。麻醉药物抑制了迷走神经完整和迷走神经切断大鼠的胃酸分泌。不能排除对壁内神经元有作用的可能性。在胃酸分泌研究中应考虑麻醉的神经抑制作用。
