Kabat Geoffrey C, Miller Anthony B, Jain Meera, Rohan Thomas E
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1306-8. doi: 10.1158/1055-9965.EPI-07-0086.
Recent studies suggest that elevated body iron levels may contribute to breast carcinogenesis; however, epidemiologic evidence is lacking. We used data from a large cohort study of Canadian women to assess breast cancer in association with total iron and heme iron intake. Among 49,654 women ages 40 to 59 followed for an average of 16.4 years, we identified 2,545 incident breast cancer cases. Data from a food frequency questionnaire administered at baseline were used to calculate total dietary iron and heme iron intake. Using Cox proportional hazards models, we found no association of iron or heme iron intake with risk of breast cancer overall, in women consuming 30+ g of alcohol per day, or in women who had ever used hormone replacement therapy. The present study offers no support for an association of iron or heme iron intake with breast cancer risk or for a modification by iron of the effect of alcohol or estrogen. However, further cohort studies with repeated measurement of iron intake are warranted.
近期研究表明，体内铁水平升高可能与乳腺癌发生有关；然而，缺乏流行病学证据。我们利用来自一项针对加拿大女性的大型队列研究的数据，评估乳腺癌与总铁摄入量和血红素铁摄入量之间的关联。在平均随访16.4年的49654名40至59岁女性中，我们确定了2545例新发乳腺癌病例。利用基线时进行的食物频率问卷调查数据，计算膳食总铁摄入量和血红素铁摄入量。使用Cox比例风险模型，我们发现，总体而言，铁或血红素铁摄入量与乳腺癌风险之间无关联，在每天饮酒30克及以上的女性中，以及在曾经使用过激素替代疗法的女性中，也无关联。本研究不支持铁或血红素铁摄入量与乳腺癌风险之间存在关联，也不支持铁对酒精或雌激素作用的修饰作用。然而，有必要进行进一步的队列研究，重复测量铁摄入量。
