Chan Valerie, Cave Andrew J, Banh Hoan Linh
Cross Cancer Institute, Alberta Health Services, Edmonton, AB, Canada.
Department of Family Medicine, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.
SAGE Open Med. 2015 May 25;3:2050312115586912. doi: 10.1177/2050312115586912. eCollection 2015.
The use of inhaled corticosteroids is the standard maintenance therapy in asthma therapy and as adjunct therapy in moderate to severe chronic obstructive pulmonary disease. A dose-related increase in fracture risk is associated with inhaled corticosteroid use; there is an inverse relationship between bone mineral density and duration and cumulative dose of inhaled corticosteroid. Adequate intake of calcium and vitamin D are cornerstones of osteoporosis prevention. The objectives are to assess whether the proportion of patients receiving inhaled corticosteroids are taking calcium and vitamin D; the association between long-term inhaled corticosteroid use and abnormal bone mineral density or fractures; and how many qualified patients received bone mineral density scans.
Patients who filled a prescription for inhaled corticosteroids at selected community pharmacies across Alberta were recruited for a survey of their osteoporosis prevention activities.
A total of 256 patients from 12 community pharmacies were included. The average age was 60 ± 17.4 years with 65% female. There were 21%, 51%, and 28% of patients on high, medium, and low dose inhaled corticosteroids, respectively. Only 17% of patients >50 years old received recommended calcium and vitamin D supplementation and 87 (73%) of the qualified patients received bone mineral density scan.
Osteoporosis prevention in inhaled corticosteroid users is currently poorly addressed. More promotion is needed to raise pharmacist awareness of the risks of inhaled corticosteroids.
吸入性糖皮质激素的使用是哮喘治疗的标准维持疗法,也是中重度慢性阻塞性肺疾病的辅助治疗方法。吸入性糖皮质激素的使用与骨折风险的剂量相关性增加有关;骨矿物质密度与吸入性糖皮质激素的使用时长和累积剂量之间呈负相关。充足的钙和维生素D摄入是预防骨质疏松症的基石。目的是评估接受吸入性糖皮质激素治疗的患者中服用钙和维生素D的比例;长期使用吸入性糖皮质激素与骨矿物质密度异常或骨折之间的关联;以及有多少符合条件的患者接受了骨矿物质密度扫描。
招募在艾伯塔省选定社区药房填写吸入性糖皮质激素处方的患者,对其骨质疏松症预防活动进行调查。
共纳入来自12家社区药房的256名患者。平均年龄为60±17.4岁,女性占65%。分别有21%、51%和28%的患者使用高、中、低剂量的吸入性糖皮质激素。50岁以上的患者中只有17%接受了推荐的钙和维生素D补充剂,87名(73%)符合条件的患者接受了骨矿物质密度扫描。
目前,吸入性糖皮质激素使用者的骨质疏松症预防工作做得很差。需要更多的宣传来提高药剂师对吸入性糖皮质激素风险的认识。