McLaren Alex C, McLaren Sandra G, Hickmon Miranda K
Banner Good Samaritan Medical Center, Phoenix, AZ, USA.
Clin Orthop Relat Res. 2007 Aug;461:60-3. doi: 10.1097/BLO.0b013e3181123e90.
Release of antibiotics from antibiotic-loaded PMMA is dependent on its permeability. Loading PMMA with soluble particulate filler has been proposed to increase permeability and antibiotic release for beads and spacers. We therefore assessed particulate sucrose, xylitol, and erythritol as fillers to increase the permeability and elution kinetics of filler-loaded PMMA. Based on lower solubility, we hypothesized that erythritol would not enhance permeability and elution as much as xylitol and sucrose. We made filler-loaded PMMA beads with each of the three fillers combined with phenolphthalein, and soaked in 0.1% NaOH solution. Permeability was assessed qualitatively by relative depth of phenolphthalein color change caused by penetration of NaOH solution into subsequently split beads. Elution was quantitatively assessed by spectrophotometric light absorption measurements of the eluent. Fluid penetration reached the center of 7-mm beads by day 15, similar for all three materials. Elution of phenolphthalein was greater for xylitol than for the other two materials. Particulate sucrose, xylitol, and erythritol fillers increase PMMA permeability and elution kinetics but relative solubility did not determine the relative degree of enhancement of permeability and elution by these materials.
载抗生素聚甲基丙烯酸甲酯（PMMA）中抗生素的释放取决于其渗透性。有人提出在PMMA中加入可溶性颗粒填料，以提高珠子和间隔物的渗透性及抗生素释放量。因此，我们评估了颗粒状蔗糖、木糖醇和赤藓糖醇作为填料，以提高负载填料的PMMA的渗透性和洗脱动力学。基于较低的溶解度，我们推测赤藓糖醇对渗透性和洗脱的增强作用不如木糖醇和蔗糖。我们制备了分别含有这三种填料并与酚酞混合的负载填料的PMMA珠子，并将其浸泡在0.1%的氢氧化钠溶液中。通过氢氧化钠溶液渗入随后劈开的珠子所引起的酚酞颜色变化的相对深度，定性评估渗透性。通过对洗脱液进行分光光度法吸光测量，定量评估洗脱情况。到第15天时，液体渗透到达了7毫米珠子的中心，三种材料的情况相似。木糖醇对酚酞的洗脱作用比其他两种材料更强。颗粒状蔗糖、木糖醇和赤藓糖醇填料可提高PMMA的渗透性和洗脱动力学，但相对溶解度并未决定这些材料对渗透性和洗脱增强的相对程度。
