Billings Caroline, Anderson David E
College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA.
Bioengineering (Basel). 2022 Feb 6;9(2):65. doi: 10.3390/bioengineering9020065.
As medicine advances and physicians are able to provide patients with innovative solutions, including placement of temporary or permanent medical devices that drastically improve quality of life of the patient, there is the persistent, recurring problem of chronic bacterial infection, including osteomyelitis. Osteomyelitis can manifest as a result of traumatic or contaminated wounds or implant-associated infections. This bacterial infection can persist as a result of inadequate treatment regimens or the presence of biofilm on implanted medical devices. One strategy to mitigate these concerns is the use of implantable medical devices that simultaneously act as local drug delivery devices (DDDs). This classification of device has the potential to prevent or aid in clearing chronic bacterial infection by delivering effective doses of antibiotics to the area of interest and can be engineered to simultaneously aid in tissue regeneration. This review will provide a background on bacterial infection and current therapies as well as current and prospective implantable DDDs, with a particular emphasis on local DDDs to combat bacterial osteomyelitis.
随着医学的进步，医生能够为患者提供创新的解决方案，包括植入临时或永久性医疗设备，这极大地提高了患者的生活质量，但慢性细菌感染（包括骨髓炎）这一持续反复出现的问题依然存在。骨髓炎可能由创伤性或受污染的伤口或植入物相关感染引起。由于治疗方案不充分或植入医疗设备上存在生物膜，这种细菌感染可能会持续存在。减轻这些担忧的一种策略是使用可同时作为局部给药装置（DDD）的植入式医疗设备。这类装置有可能通过向感兴趣的区域递送有效剂量的抗生素来预防或帮助清除慢性细菌感染，并且可以设计成同时有助于组织再生。本综述将提供关于细菌感染和当前治疗方法的背景知识，以及当前和未来的植入式DDD，特别强调用于对抗细菌性骨髓炎的局部DDD。
