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Clin Orthop Relat Res. 2010 Aug;468(8):2101-6. doi: 10.1007/s11999-010-1264-1.
Adding soluble particulate poragens to antimicrobial-loaded bone cement increases the permeability of the bone cement and increases the antimicrobial release, but the mechanical effect of adding poragens is not well known.
QUESTIONS/PURPOSES: We therefore asked the following questions: (1) Does the poragen fraction in antimicrobial-loaded bone cement affect its antimicrobial release? (2) Does poragen fraction in antimicrobial-loaded bone cement affect its compressive strength; and (3) Does the effect on compressive strength change over time in elution?
Antimicrobial-loaded bone cement made in the proportions of 40 g polymer powder, 20 mL monomer liquid, 1 g tobramycin powder and one of six different doses of poragen powder (0, 1, 2, 4, 8, or 16 g of particulate xylitol per batch) was formed into standardized test cylinders and eluted for 30 days. We determined the cumulative recovered tobramycin and the change in compressive strength over 30 days of elution.
Antimicrobial release progressively increased with increasing poragen fraction. Compressive strength progressively decreased with increasing poragen fraction and with increasing time in elution. Poragen fractions greater than 2 g per batch caused the compressive strength to decrease below 70 MPa over 30 days of elution.
The use of poragens can increase elution of antimicrobials from antimicrobial-loaded bone cement. However, for implant fixation, to avoid deleterious reduction of compressive strength, the amount of poragen that can be added in addition to 1 g of antimicrobial powder may be limited to 2 g per batch.
在载抗菌剂骨水泥中添加可溶颗粒状助悬剂会增加骨水泥的通透性并增加抗菌剂的释放，但添加助悬剂的机械效果尚不清楚。
问题/目的：因此，我们提出了以下问题：（1）载抗菌剂骨水泥中的助悬剂部分是否会影响其抗菌释放？（2）载抗菌剂骨水泥中的助悬剂部分是否会影响其抗压强度；（3）在洗脱过程中，抗压强度的影响是否随时间而变化？
以 40 g 聚合物粉末、20 mL 单体液体、1 g 妥布霉素粉末和 6 种不同剂量的助悬剂粉末（每批 0、1、2、4、8 或 16 g 颗粒木糖醇）的比例制备载抗菌剂骨水泥，制成标准测试圆柱并洗脱 30 天。我们测定了累积回收的妥布霉素和洗脱 30 天内抗压强度的变化。
抗菌剂释放量随助悬剂分数的增加而逐渐增加。抗压强度随助悬剂分数的增加和洗脱时间的增加而逐渐降低。每批助悬剂分数大于 2 g 会导致抗压强度在洗脱 30 天内降至 70 MPa 以下。
助悬剂的使用可以增加载抗菌骨水泥中抗菌剂的洗脱。然而，为了固定植入物，为避免抗压强度的有害降低，除 1 g 抗菌粉末外，可添加的助悬剂的量可能限制在每批 2 g 以内。
