Mizota Atsushi, Asaumi Noriko, Takasoh Michihiko, Adachi-Usami Emiko
Department of Ophthalmology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, 279-0021, Japan.
Doc Ophthalmol. 2007 Sep;115(2):105-9. doi: 10.1007/s10633-007-9062-0. Epub 2007 Jun 5.
A delay of the peak latency of the pattern visual evoked cortical potentials (pVEP) is accepted as one of the paraclinical evidence for a diagnosis of multiple sclerosis (MS). The purpose of this study was to evaluate the pVEPs in Japanese patients with MS without a history of visual pathway involvement. We studied the medical records of 29 MS patients without any history of visual pathway involvement, and with visual acuity correctable to > or = 20/20. The Goldmann visual fields, pupillary light reflexes, and optic disks were normal in all. pVEPs elicited by 3 rev/s (transient) and 12 rev/s (steady-state) were recorded from the MS patients and compared with those recorded from normal subjects. The latency of the P100 component of the transient pVEPs was significantly prolonged in 9/29 (31%) MS patients. A phase lag in the steady-state pVEPs was found in 6/29 (21%) MS patients, and the mean amplitude was significantly smaller. The incidence of cases with abnormal pVEPs is lower than that reported from Europe and United State. This difference is possibly due to racial differences, and the use of different criteria for diagnosing optic neuritis.
模式视觉诱发电位（pVEP）的峰潜伏期延迟被认为是多发性硬化症（MS）诊断的副临床证据之一。本研究的目的是评估无视觉通路受累病史的日本MS患者的pVEP。我们研究了29例无任何视觉通路受累病史且视力可矫正至≥20/20的MS患者的病历。所有患者的戈德曼视野、瞳孔对光反射和视盘均正常。记录了MS患者由3次/秒（瞬态）和12次/秒（稳态）刺激诱发的pVEP，并与正常受试者记录的pVEP进行比较。在29例MS患者中有9例（31%）瞬态pVEP的P100成分潜伏期显著延长。在29例MS患者中有6例（21%）稳态pVEP存在相位滞后，且平均振幅显著较小。pVEP异常的病例发生率低于欧洲和美国报道的发生率。这种差异可能是由于种族差异以及诊断视神经炎的标准不同所致。
