Borda Luis J, Wong Lulu L, Tosti Antonella
Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.
Dermatol Online J. 2019 Jan 15;25(1):13030/qt4c20m28z.
Hormone replacement therapy has been shown to be effective in alleviating menopausal symptoms. However, its use is controversial owing to potential health risks, such as thromboembolism and cancer. Bioidentical hormone therapy has recently become popular as an alternative to conventional hormone replacement therapy. These bioidentical hormones have a molecular structure identical to endogenous hormones found in a woman's body. A claimed advantage of bioidentical hormone therapy is the compounding practice in order to individualize therapy depending on patient's own hormone levels and symptoms. However, there is no scientific evidence to assess the validity of these claims. Bioidentical hormone therapy has also been used by dermatologists for its anti-aging effects on the skin, but little is known about efficacy and side effects of bioidentical hormones in this field. This review illustrates the main purpose of bioidentical hormone therapy for dermatological uses and its potential side effects, serving as a tool for dermatologists when facing these patients.
激素替代疗法已被证明在缓解更年期症状方面有效。然而，由于存在潜在的健康风险，如血栓栓塞和癌症，其使用存在争议。生物同源激素疗法最近作为传统激素替代疗法的替代品而受到欢迎。这些生物同源激素的分子结构与女性体内发现的内源性激素相同。生物同源激素疗法的一个所谓优势是根据患者自身的激素水平和症状进行个体化治疗的配药实践。然而，没有科学证据来评估这些说法的有效性。皮肤科医生也因生物同源激素对皮肤的抗衰老作用而使用它，但在该领域，人们对生物同源激素的疗效和副作用知之甚少。本综述阐述了生物同源激素疗法在皮肤科应用的主要目的及其潜在副作用，为皮肤科医生面对这些患者时提供参考。
