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前庭神经鞘瘤患者致残性眩晕的经迷路手术

Translabyrinthine surgery for disabling vertigo in vestibular schwannoma patients.

作者信息

Godefroy W P, Hastan D, van der Mey A G L

机构信息

Department of Otolaryngology, Leiden University Medical Centre, Leiden, The Netherlands.

出版信息

Clin Otolaryngol. 2007 Jun;32(3):167-72. doi: 10.1111/j.1365-2273.2007.01427.x.

Abstract

OBJECTIVE

To determine the impact of translabyrinthine surgery on the quality of life in vestibular schwannoma patients with rotatory vertigo.

STUDY DESIGN

Prospective study in 18 vestibular schwannoma patients.

SETTING

The study was conducted in a multispecialty tertiary care clinic.

PARTICIPANTS

All 18 patients had a unilateral intracanalicular vestibular schwannoma, without serviceable hearing in the affected ear and severely handicapped by attacks of rotatory vertigo and constant dizziness. Despite an initial conservative treatment, extensive vestibular rehabilitation exercises, translabyrinthine surgery was performed because of the disabling character of the vertigo, which considerably continued to affect the patients' quality of life.

MAIN OUTCOME MEASURES

Preoperative and postoperative quality of life using the Short Form 36 Health Survey (Short Form-36) scores and Dizziness Handicap Inventory (DHI) scores.

RESULTS

A total of 17 patients (94%) completed the questionnaire preoperatively and 3 and 12 months postoperatively. All Short Form-36 scales of the studied patients scored significantly lower when compared with the healthy Dutch control sample (P < 0.05). There was a significant improvement of DHI total scores and Short Form-36 scales on physical and social functioning, role-physical functioning, role-emotional functioning, mental health and general health at 12 months after surgery when compared with preoperative scores (P < 0.05).

CONCLUSIONS

Vestibular schwannoma patients with disabling vertigo, experience significant reduced quality of life when compared with a healthy Dutch population. Translabyrinthine tumour removal significantly improved the patients' quality of life. Surgical treatment should be considered in patients with small- or medium-sized tumours and persisting disabling vertigo resulting in a poor quality of life.

摘要

目的

确定经迷路手术对患有旋转性眩晕的前庭神经鞘瘤患者生活质量的影响。

研究设计

对18例前庭神经鞘瘤患者进行前瞻性研究。

研究地点

该研究在一家多专科三级护理诊所进行。

研究对象

所有18例患者均患有单侧内听道前庭神经鞘瘤,患耳无有效听力,因旋转性眩晕发作和持续性头晕而严重致残。尽管最初进行了保守治疗和广泛的前庭康复训练,但由于眩晕的致残性持续严重影响患者的生活质量,故进行了经迷路手术。

主要观察指标

使用简明健康调查问卷(Short Form-36)评分和头晕残障量表(DHI)评分评估术前和术后的生活质量。

结果

共有17例患者(94%)在术前、术后3个月和12个月完成了问卷调查。与健康的荷兰对照样本相比,所有研究患者的简明健康调查问卷各量表得分均显著较低(P<0.05)。与术前评分相比,术后12个月时,头晕残障量表总分以及简明健康调查问卷在身体和社会功能、角色-身体功能、角色-情感功能、心理健康和总体健康方面的量表得分均有显著改善(P<0.05)。

结论

与健康的荷兰人群相比,患有致残性眩晕的前庭神经鞘瘤患者生活质量显著降低。经迷路肿瘤切除术显著改善了患者的生活质量。对于患有中小型肿瘤且持续存在致残性眩晕导致生活质量较差的患者,应考虑手术治疗。

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