Copper M P, Triesscheijn M, Tan I B, Ruevekamp M C, Stewart F A
Department of Head and Neck Surgery, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Clin Otolaryngol. 2007 Jun;32(3):185-9. doi: 10.1111/j.1365-2273.2007.01441.x.
Multiple primary tumours are a common problem in the head and neck cancer patients. Curative surgery or radiotherapy of these tumours can be very mutilating or even impossible. This study aims at evaluating meta-tetrahydroxy-phenyl chlorin-mediated photodynamic therapy for second or multiple primary tumours in the head and neck.
Retrospective study of all patients with second or multiple primary tumours treated by photodynamic therapy over a 10-year period.
All patients were treated in the Netherlands Cancer Institute, a tertiary referral centre for the head and neck cancer patients.
A total of 27 patients with 42 the second or the multiple primary head and neck tumours were treated by photodynamic therapy (0.15 mg/kg meta-tetrahydroxy-phenyl chlorin).
Cure rates.
Twenty-eight of 42 tumours were cured (67%). Cure rates for stage I or in situ disease were 85%versus 38% for stage II/III.
Cure rates for photodynamic therapy of the multiple primary head and neck tumours were lower than previously described for first primaries, but were still very encouraging for this difficult patient population. The high cure rate obtained in stage I multiple primaries emphasises the importance of a meticulous follow-up of patients treated for the head and neck cancer to detect new tumours at a curable stage.
多原发性肿瘤是头颈癌患者的常见问题。对这些肿瘤进行根治性手术或放疗可能会造成严重毁容甚至无法进行。本研究旨在评估间四羟基苯基二氢卟吩介导的光动力疗法对头颈部第二或多原发性肿瘤的疗效。
对10年间接受光动力疗法治疗的所有第二或多原发性肿瘤患者进行回顾性研究。
所有患者均在荷兰癌症研究所接受治疗，该研究所是头颈癌患者的三级转诊中心。
共有27例患者的42个第二或多原发性头颈肿瘤接受了光动力疗法（0.15 mg/kg间四羟基苯基二氢卟吩）治疗。
治愈率。
42个肿瘤中有28个治愈（67%）。I期或原位疾病的治愈率为85%，而II/III期为38%。
多原发性头颈肿瘤光动力疗法的治愈率低于先前报道的第一原发性肿瘤，但对于这一困难的患者群体来说仍非常令人鼓舞。I期多原发性肿瘤获得的高治愈率强调了对头颈癌治疗患者进行细致随访以在可治愈阶段发现新肿瘤的重要性。
