Muoio Deborah M
Sarah W. Stedman Nutrition and Metabolism Center and Departments of Pharmacology & Cancer Biology and Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Cell Metab. 2007 Jun;5(6):412-4. doi: 10.1016/j.cmet.2007.05.011.
Thioredoxin-interacting protein (TXNIP) binds and inhibits the reducing activity of thioredoxin. A new study (Parikh et al., 2007) implicates this redox rheostat as a negative regulator of peripheral glucose metabolism in humans. Investigators combined human physiology, genomic screening, and cell-based genetic studies to highlight TNXIP as a potential culprit in the pathogenesis of type 2 diabetes.
硫氧还蛋白相互作用蛋白（TXNIP）可结合并抑制硫氧还蛋白的还原活性。一项新研究（帕里克等人，2007年）表明，这种氧化还原调节蛋白是人类外周葡萄糖代谢的负调节因子。研究人员结合人体生理学、基因组筛选和细胞遗传学研究，强调TXNIP是2型糖尿病发病机制中的一个潜在罪魁祸首。
