Department of Emergency, Provincial Hospital Affiliated to Shandong University, Ji-nan 250021, China.
Acta Pharmacol Sin. 2011 Jul;32(7):873-8. doi: 10.1038/aps.2011.26. Epub 2011 May 23.
Omentin-1, a novel adipokine expressed in visceral adipose tissue, is negatively correlated with insulin resistance and obesity. Decreased omentin-1 expression has been found in many chronic inflammatory diseases. However, the role of omentin-1 in coronary artery disease (CAD) has not been elucidated. The aim of the present study was to determine whether serum concentration of omentin-1 was independently associated with CAD.
One hundred and fifty five patients with CAD were divided into two groups: acute coronary syndrome (ACS) and stable angina pectoris (SAP). A total of 52 healthy participants served as controls. Serum concentrations of omentin-1 and interleukin-6 (IL-6) were measured using ELISA. The association of omentin-1 with CAD and cardiovascular disease risk factors was evaluated.
Serum omentin-1 levels were lower in patients with ACS or SAP compared with controls (ACS, 113.08±61.43 ng/mL; SAP, 155.41±66.89 ng/mL; control, 254.00±72.9 ng/mL; P<0.01). Patients with ACS also had lower serum concentrations of omentin-1 compared with patients with SAP (P<0.01). Serum concentration of omentin-1 was negatively correlated with body mass index (r=-0.17, P<0.05) and serum IL-6 concentration (r=-0.19, P<0.05). Furthermore, multiple logistic regression analysis showed that serum omentin-1 concentrations were independently correlated with CAD.
The findings suggest that serum concentrations of omentin-1 are related to CAD.
内脂素-1 是一种在内脏脂肪组织中表达的新型脂肪因子，与胰岛素抵抗和肥胖呈负相关。许多慢性炎症性疾病中发现内脂素-1 的表达降低。然而，内脂素-1 在冠状动脉疾病（CAD）中的作用尚未阐明。本研究旨在确定血清内脂素-1 浓度是否与 CAD 独立相关。
155 例 CAD 患者分为急性冠脉综合征（ACS）和稳定型心绞痛（SAP）两组。共 52 名健康参与者作为对照组。采用 ELISA 法测定血清内脂素-1 和白细胞介素-6（IL-6）浓度。评估内脂素-1 与 CAD 和心血管疾病危险因素的关系。
ACS 或 SAP 患者的血清内脂素-1 水平低于对照组（ACS：113.08±61.43ng/mL；SAP：155.41±66.89ng/mL；对照组：254.00±72.9ng/mL；P<0.01）。ACS 患者的血清内脂素-1 水平也低于 SAP 患者（P<0.01）。血清内脂素-1 浓度与体重指数（r=-0.17，P<0.05）和血清 IL-6 浓度（r=-0.19，P<0.05）呈负相关。此外，多元逻辑回归分析表明，血清内脂素-1 浓度与 CAD 独立相关。
研究结果表明，血清内脂素-1 浓度与 CAD 相关。
