gyrA mutations in fluoroquinolone-resistant Clostridium difficile PCR-027.
作者信息
Drudy Denise, Kyne Lorraine, O'Mahony Rebecca, Fanning Séamus
出版信息
Emerg Infect Dis. 2007 Mar;13(3):504-5. doi: 10.3201/eid1303.060771.
Abstract
摘要
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High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile.与毒素A阴性、毒素B阳性艰难梭菌gyrB基因新突变相关的对莫西沙星和加替沙星的高水平耐药性。
J Antimicrob Chemother. 2006 Dec;58(6):1264-7. doi: 10.1093/jac/dkl398. Epub 2006 Oct 3.
2
Emergence of Clostridium difficile-associated disease in North America and Europe.北美和欧洲艰难梭菌相关疾病的出现。
Clin Microbiol Infect. 2006 Oct;12 Suppl 6:2-18. doi: 10.1111/j.1469-0691.2006.01580.x.
3
Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe.一种新出现的艰难梭菌菌株产生毒素，该菌株与北美和欧洲的严重疾病暴发有关。
Lancet. 2005;366(9491):1079-84. doi: 10.1016/S0140-6736(05)67420-X.
4
Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem.克林霉素、头孢菌素、氟喹诺酮类药物与艰难梭菌相关性腹泻：这是一个抗菌药物耐药性问题。
Clin Infect Dis. 2004 Mar 1;38(5):646-8. doi: 10.1086/382084. Epub 2004 Feb 11.
5
gyrA and gyrB mutations are implicated in cross-resistance to Ciprofloxacin and moxifloxacin in Clostridium difficile.gyrA和gyrB突变与艰难梭菌对环丙沙星和莫西沙星的交叉耐药性有关。
Antimicrob Agents Chemother. 2002 Nov;46(11):3418-21. doi: 10.1128/AAC.46.11.3418-3421.2002.
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Clostridium difficile.艰难梭菌
Gastroenterol Clin North Am. 2001 Sep;30(3):753-77, ix-x. doi: 10.1016/s0889-8553(05)70209-0.
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Mechanisms of fluoroquinolone resistance.氟喹诺酮耐药机制。
Drug Resist Updat. 1999 Feb;2(1):38-55. doi: 10.1054/drup.1998.0068.
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Resistance to moxifloxacin in toxigenic Clostridium difficile isolates is associated with mutations in gyrA.产毒艰难梭菌分离株对莫西沙星的耐药性与gyrA基因突变有关。
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N Engl J Med. 1999 Nov 25;341(22):1645-51. doi: 10.1056/NEJM199911253412203.
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