Balamurugan M, Parthasarathi K, Cooper E L, Ranganathan L S
Division of Vermibiotechnology, Department of Zoology, Annamalai University, Annamalainagar, India.
Eur Rev Med Pharmacol Sci. 2007 Mar-Apr;11(2):77-90.
Experiments were conducted to understand the therapeutic properties such as anti-inflammatory, anti-oxidative, haematological and serum biochemical markers of earthworm paste (EP) derived from an indigenous species Lampito mauritii (Kinberg), in comparison with the standard anti-inflammatory drug- aspirin, on Wistar albino rat (Rattus norvegicus). Administration of earthworm paste of Lampito mauritii at the rate of 80 mg/kg into albino rats which were induced of inflammation, was found to reduce inflammation, restore the levels of antioxidants-reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and thiobarbituric acid reactive substances, normalise the values of erythrocyte, leukocyte, differential levels of neutrophils, lymphocytes, eosinophils, haemoglobin and serum biochemical contents e.g., protein, albumin, glucose, cholesterol, acid and alkaline phosphatase, electrolytes e.g., sodium, potassium and chloride. The anti-inflammatory activity together with antioxidant property of EP seems to be due to the high polyphenolic content of earthworm tissue.
进行了实验，以了解源自本土物种毛里求斯腔蚓（金伯格）的蚯蚓膏（EP）的抗炎、抗氧化、血液学和血清生化指标等治疗特性，并与标准抗炎药物阿司匹林进行比较，实验对象为Wistar白化大鼠（褐家鼠）。以80mg/kg的剂量给诱导炎症的白化大鼠施用毛里求斯腔蚓的蚯蚓膏，发现其可减轻炎症，恢复抗氧化剂还原型谷胱甘肽、谷胱甘肽过氧化物酶、超氧化物歧化酶、过氧化氢酶和硫代巴比妥酸反应性物质的水平，使红细胞、白细胞、中性粒细胞、淋巴细胞、嗜酸性粒细胞的分类水平、血红蛋白和血清生化成分（如蛋白质、白蛋白、葡萄糖、胆固醇、酸性和碱性磷酸酶）以及电解质（如钠、钾和氯）的值正常化。EP的抗炎活性和抗氧化特性似乎归因于蚯蚓组织中高含量的多酚。
