Department of Biochemistry, University of Kerala, Thiruvananthapuram, India.
Immunopharmacol Immunotoxicol. 2010 Dec;32(4):569-75. doi: 10.3109/08923970903584890. Epub 2010 Feb 5.
The present study was aimed to establish the efficacy of Jeevaneeya Rasayana (JR), an ayurvedic polyherbal formulation, in adjuvant-induced arthritic (AIA) rat model with reference to mediators of inflammation. The methanolic (MJR), ethanolic (EJR), and water extracts (WJR) of JR were prepared and their anti-inflammatory activity in carrageenan-induced acute model was evaluated. MJR at a dose of 25 mg/kg showed significantly higher anti-inflammatory effect than EJR, WJR, and standard drug diclofenac. MJR also significantly decreased the paw edema in AIA rats. Activities of cyclooxygenase, 5-lipoxygenase, and myeloperoxidase were decreased significantly on treatment with MJR. Supplementation with MJR increases the activities of antioxidant enzymes and the level of glutathione content. The increment in the concentration of C-reactive protein, thiobarbituric acid reactive substance, and ceruloplasmin observed in arthritic rats were found to be significantly restored in MJR treated rats. Thus, the results demonstrated the potential beneficiary effect of methanolic extract of Jeevaneeya Rasayana on acute and chronic models of inflammation.
本研究旨在评估基于炎症介质的阿育吠陀复方草药制剂 Jeevaneeya Rasayana（JR）在佐剂诱导性关节炎（AIA）大鼠模型中的疗效。制备了 JR 的甲醇（MJR）、乙醇（EJR）和水提取物（WJR），并评估了它们在角叉菜胶诱导的急性模型中的抗炎活性。MJR 在 25mg/kg 剂量下显示出比 EJR、WJR 和标准药物双氯芬酸更高的抗炎作用。MJR 还显著降低了 AIA 大鼠的足肿胀。用 MJR 治疗可显著降低环加氧酶、5-脂加氧酶和髓过氧化物酶的活性。补充 MJR 可增加抗氧化酶的活性和谷胱甘肽含量。在关节炎大鼠中观察到的 C 反应蛋白、硫代巴比妥酸反应物质和铜蓝蛋白浓度的增加，在 MJR 治疗的大鼠中发现得到了显著恢复。因此，这些结果表明，甲醇提取物 Jeevaneeya Rasayana 对急性和慢性炎症模型具有潜在的有益作用。
