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[决明子蛋白及蒽醌苷对D-半乳糖致衰老小鼠学习记忆能力及相关物质的影响]

[Effect of protein and anthraquinone glucosides from Semen Cassia on learning and memory capacity and related substances of senile mice induced by D-galactose].

作者信息

Liu Jin-Zhu, Lin Xiang, Li Xu-E, Guo Bao-Jang

机构信息

College of life science, South China Normal University, Guangzhou 510631, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2007 Mar;32(6):516-9.

PMID:17552159
Abstract

OBJECTIVE

To investigate actions of protein and anthraquinone glucosides from Semen Cassia on learning and memory capacity and related substances of senile mice induced by D-galactose.

METHOD

The subacute senile mouse models induced by injection of D-galactose subcutaneously were used.

RESULT

Protein and anthraquinone glucosides from Semen Cassia could improve the learning and memory capacity of senile mice. Protein and anthraquinone glucosides from Semen Cassia not only inhibited the increase of malondialdehyde (MDA) in cerebrum of senile mice, but also enhanced the level of superoxide dismutase (SOD) in cerebrum and lessened the lipofuscin (LF) in liver tissue of senile mice. Protein from Semen Cassia could reduce the content of monoamine oxidase (MAO) in cerebrum of senile mice.

CONCLUSION

Protein and anthraquinone glucosides from Semen Cassia could improve the learning and memory capacity of senile mice and delay aging.

摘要

目的

研究决明子中蛋白质和蒽醌苷对D-半乳糖致衰老小鼠学习记忆能力及相关物质的影响。

方法

采用皮下注射D-半乳糖诱导的亚急性衰老小鼠模型。

结果

决明子中蛋白质和蒽醌苷可提高衰老小鼠的学习记忆能力。决明子中蛋白质和蒽醌苷不仅抑制衰老小鼠大脑中丙二醛(MDA)含量的增加,还提高大脑中超氧化物歧化酶(SOD)水平,减少衰老小鼠肝组织中脂褐素(LF)含量。决明子中蛋白质可降低衰老小鼠大脑中单胺氧化酶(MAO)含量。

结论

决明子中蛋白质和蒽醌苷可提高衰老小鼠的学习记忆能力,延缓衰老。

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