亨廷顿舞蹈症患者血浆的蛋白质组分析揭示了神经炎症激活和生物标志物候选物。
Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates.
作者信息
Dalrymple Annette, Wild Edward J, Joubert Richard, Sathasivam Kirupa, Björkqvist Maria, Petersén Asa, Jackson Graham S, Isaacs Jeremy D, Kristiansen Mark, Bates Gillian P, Leavitt Blair R, Keir Geoff, Ward Malcolm, Tabrizi Sarah J
机构信息
Proteome Sciences PLC, Cobham, Surrey, United Kingdom.
出版信息
J Proteome Res. 2007 Jul;6(7):2833-40. doi: 10.1021/pr0700753. Epub 2007 Jun 7.
Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.
亨廷顿舞蹈症（HD）会导致中枢神经系统广泛变化以及包括内分泌和免疫功能障碍在内的全身异常。需要HD生物标志物来推动潜在治疗方法的临床试验。我们使用多平台蛋白质组学分析来揭示HD进展过程中血浆的变化。在来自两个群体（脑脊液和R6/2小鼠）的血浆中，通过免疫印迹和酶联免疫吸附测定法对感兴趣的蛋白质进行了评估。所鉴定出的蛋白质表明HD存在神经炎症，值得作为可能的生物标志物作进一步研究。
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