Yao Cheng-Can, Yao Ping, Wu Hao, Zha Zhen-Gang
College of Pharmacy, Jinan University, Guangzhou, 510632, PR China.
J Mater Sci Mater Med. 2007 Oct;18(10):1969-72. doi: 10.1007/s10856-007-3093-7. Epub 2007 Jun 7.
Recombinant human basic fibroblast growth factor (rhbFGF) is a peptide with many bioactivities such as promoting proliferation and migration of various cells. It plays an important role in neuroprotection and enhancement of nerve regeneration. Due to its short half-life in the body, local administration by injection is limited. To prolong the bioactivity of rhbFGF and to enhance its biological effects, absorbable collagen sponge was used as matrixes and carriers for controlled release of rhbFGF. The effects of rhbFGF soaked into an absorbable collagen sponge (rhbFGF/ACS) for the repair of rat sciatic nerve injury were evaluated. The functional, electrophysiological and histological examinations demonstrate the treatment with rhbFGF/ACS can enhance rat sciatic nerve repair, and its effectiveness is better than free rhbFGF alone. It is concluded the rhbFGF/ACS is a promising biomaterial to improve the repair and regeneration of sciatic nerve injury.
重组人碱性成纤维细胞生长因子（rhbFGF）是一种具有多种生物活性的肽，如促进各种细胞的增殖和迁移。它在神经保护和增强神经再生方面发挥着重要作用。由于其在体内半衰期较短，注射局部给药受到限制。为了延长rhbFGF的生物活性并增强其生物学效应，可吸收胶原海绵被用作rhbFGF控释的基质和载体。评估了浸泡在可吸收胶原海绵中的rhbFGF（rhbFGF/ACS）对大鼠坐骨神经损伤修复的作用。功能、电生理和组织学检查表明，rhbFGF/ACS治疗可增强大鼠坐骨神经修复，其效果优于单独使用游离rhbFGF。结论是rhbFGF/ACS是一种有前景的生物材料，可改善坐骨神经损伤的修复和再生。
