Myers Kendall P, Setterquist Sharon F, Capuano Ana W, Gray Gregory C
Center for Emerging Infectious Diseases, Department of Epidemiology, University of Iowa, Iowa City, IA 52242-5000, USA.
Clin Infect Dis. 2007 Jul 1;45(1):4-9. doi: 10.1086/518579. Epub 2007 May 24.
Pandemic influenza virus strains originate in avian species. We examined veterinarians in the United States for evidence of previous avian influenza virus infection.
We performed a controlled, cross-sectional seroprevalence study among 42 veterinarians and 66 healthy control subjects using serum samples collected from 2002 through 2004. Serum samples were tested using a microneutralization assay against 9 influenza A virus strains.
Using multivariable logistic regression modeling, veterinarians exposed to birds demonstrated statistically significant elevated titers against the H5, H6, and H7 avian influenza virus isolates, compared with control subjects.
These data suggest that occupational exposure to avian species may increase veterinarians' risk of avian influenza virus infection. Veterinarians should be considered for priority access to vaccines and antiviral drugs in pandemic planning.
大流行性流感病毒株起源于禽类。我们对美国的兽医进行了检查,以寻找先前感染禽流感病毒的证据。
我们使用2002年至2004年采集的血清样本,对42名兽医和66名健康对照者进行了一项对照横断面血清阳性率研究。血清样本采用微量中和试验针对9种甲型流感病毒株进行检测。
使用多变量逻辑回归模型,与对照者相比,接触禽类的兽医针对H5、H6和H7禽流感病毒分离株的滴度在统计学上显著升高。
这些数据表明,职业性接触禽类可能会增加兽医感染禽流感病毒的风险。在大流行规划中,应考虑优先为兽医提供疫苗和抗病毒药物。