伏立康唑对皮肤癣菌、短帚霉及其他引起甲真菌病的机会性真菌的体外活性。
In vitro activity of voriconazole against dermatophytes, Scopulariopsis brevicaulis and other opportunistic fungi as agents of onychomycosis.
作者信息
Carrillo-Muñoz A J, Giusiano G, Guarro J, Quindós G, Guardia C, del Valle O, Rodríguez V, Estivill D, Cárdenes C D
机构信息
Departamento de Microbiología, ACIA, PO Box 10178, E-08010 Barcelona, Spain.
出版信息
Int J Antimicrob Agents. 2007 Aug;30(2):157-61. doi: 10.1016/j.ijantimicag.2007.04.004. Epub 2007 Jun 6.
Using a reference microdilution method, we studied the antifungal susceptibility to voriconazole and fluconazole of 304 clinical isolates from four species of onychomycosis-causing dermatophytes, 196 isolates of dermatophytes not related to nail infection as well as Scopulariopsis brevicaulis, Fusarium spp. and Scytalidium dimidiatum. Results showed a high antifungal activity of voriconazole against dermatophytes (geometric mean minimal inhibitory concentration (MIC)=1.14 microg/mL; MIC for 50% of the organisms (MIC(50))=0.062 miccrog/mL; MIC for 90% of the organisms (MIC(90))=0.25 microg/mL). For S. brevicaulis, the in vitro activity of voriconazole was considerably lower (geometric mean MIC=8.52 microg/mL; MIC(50) and MIC(90)=16 microg/mL). Although voriconazole is not among the drugs recommended for the management of onychomycosis, it can be a useful alternative for recalcitrant infections.
采用参考微量稀释法，我们研究了304株来自4种引起甲癣的皮肤癣菌的临床分离株、196株与指甲感染无关的皮肤癣菌以及短帚霉、镰刀菌属和双态帚霉对伏立康唑和氟康唑的抗真菌敏感性。结果显示，伏立康唑对皮肤癣菌具有较高的抗真菌活性（几何平均最低抑菌浓度（MIC）=1.14μg/mL；50%受试菌的MIC（MIC50）=0.062μg/mL；90%受试菌的MIC（MIC90）=0.25μg/mL）。对于短帚霉，伏立康唑的体外活性显著较低（几何平均MIC=8.52μg/mL；MIC50和MIC90=16μg/mL）。尽管伏立康唑并非推荐用于治疗甲癣的药物，但对于难治性感染它可能是一种有用的替代药物。
Zotero 插件