Koroleva G A, Lashkevich V A, Voroshilova M K
Vopr Virusol. 1975 Jul-Aug(4):445-9.
The capacity of vaccine and virulent strains of poliomyelitis virus to multiply in laboratory animals of different species was studied. Virus reproduction was judged by formation of photoresistant virus progeny in response to inoculation of the animals with photosensitized virus. Multiplication of virulent poliomyelitis virus strains observed in the majority of animal species examined (monkeys, newborn and adult cotton rats, newborn and adult white mice, chickens, chick embryos) resulted in active formation of photoresistant virus population and in some cases was accompanied by clinical symptoms of the disease. Multiplication of vaccine strains was observed in a smaller number of animal species and was limited, as a rule. Among non-primate animals, newborn cotton rats were most susceptible to poliovirus infection. Newborn guinea pigs were the only species of laboratory animals in which no multiplication of any of the six strains under study could be detected.
研究了脊髓灰质炎病毒的疫苗株和强毒株在不同物种实验动物体内繁殖的能力。通过给动物接种光敏化病毒后产生抗光病毒子代来判断病毒繁殖情况。在所检测的大多数动物物种（猴子、新生和成年棉鼠、新生和成年小白鼠、鸡、鸡胚）中观察到，强毒株脊髓灰质炎病毒的繁殖导致了抗光病毒群体的活跃形成，在某些情况下还伴有疾病的临床症状。疫苗株的繁殖在较少的动物物种中被观察到，且通常受到限制。在非灵长类动物中，新生棉鼠对脊髓灰质炎病毒感染最为敏感。新生豚鼠是唯一一种在所研究的六种毒株中均未检测到繁殖的实验动物物种。
