变应性肉芽肿性血管炎的结膜受累情况。
Conjunctival involvement in Churg-Strauss syndrome.
作者信息
Margolis Ron, Kosmorsky Gregory S, Lowder Careen Y, Schoenfield Lynn
机构信息
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
出版信息
Ocul Immunol Inflamm. 2007 Mar-Apr;15(2):113-5. doi: 10.1080/09273940701299388.
PURPOSE
To describe an unusual case of Churg-Strauss syndrome (CSS) that presented with a conjunctival nodule and was successfully treated with oral corticosteroids.
METHODS
Case report.
RESULTS
A 30-year-old woman with a history of adult-onset asthma, seasonal allergies, and a lung mass presented with a nodular elevation of the conjunctiva. Excisional biopsy demonstrated necrotizing eosinophilic granulomas. Systemic evaluation revealed peripheral eosinophilia and elevated IgE, consistent with Churg-Strauss syndrome. The patient's symptoms and eosinophilia resolved after an increase in the dose of oral corticosteroids.
CONCLUSIONS
This case describes a unique presentation of conjunctival involvement in CSS that differs from prior case reports by having a small, well-demarcated nodule and lacking signs of active inflammation.
目的
描述一例罕见的变应性肉芽肿性血管炎（CSS）病例，该病例以结膜结节为表现，经口服糖皮质激素治疗成功。
方法
病例报告。
结果
一名30岁女性，有成人发作性哮喘、季节性过敏和肺部肿块病史，出现结膜结节状隆起。切除活检显示坏死性嗜酸性肉芽肿。全身评估显示外周嗜酸性粒细胞增多和IgE升高，符合变应性肉芽肿性血管炎。增加口服糖皮质激素剂量后，患者的症状和嗜酸性粒细胞增多症得到缓解。
结论
本病例描述了变应性肉芽肿性血管炎累及结膜的一种独特表现，与先前的病例报告不同，其表现为一个小的、边界清晰的结节，且无活动性炎症迹象。
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