Piwi蛋白的成熟

The coming of age for Piwi proteins.

作者信息

Seto Anita G, Kingston Robert E, Lau Nelson C

机构信息

Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

出版信息

Mol Cell. 2007 Jun 8;26(5):603-9. doi: 10.1016/j.molcel.2007.05.021.

DOI:10.1016/j.molcel.2007.05.021

PMID:17560367

Abstract

Piwi proteins, a subfamily of Argonaute (Ago) proteins, have recently been shown to bind endogenous small RNAs. However, differences between Ago proteins (which bind microRNAs and small interfering RNAs) and Piwi proteins and Piwi-interacting RNAs (piRNAs) suggest novel functions for Piwi proteins. Here, we highlight the recent progress in understanding Piwi function and the implications for germline and stem cell development.

摘要

Piwi蛋白是Argonaute（Ago）蛋白家族的一个亚家族，最近研究表明它能结合内源性小RNA。然而，Ago蛋白（结合微小RNA和小干扰RNA）与Piwi蛋白及Piwi相互作用RNA（piRNA）之间的差异表明Piwi蛋白具有新功能。在此，我们着重介绍了在理解Piwi功能方面的最新进展及其对生殖系和干细胞发育的影响。