Peters Lasse, Meister Gunter
Laboratory of RNA Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.
Mol Cell. 2007 Jun 8;26(5):611-23. doi: 10.1016/j.molcel.2007.05.001.
Small regulatory RNAs such as short interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi interacting RNAs (piRNAs) have been discovered in the past, and it is becoming more and more apparent that these small molecules have key regulatory functions. Small RNAs are found in all higher eukaryotes and play important roles in cellular processes as diverse as development, stress response, or transposon silencing. Soon after the discovery of small regulatory RNAs, members of the Argonaute protein family were identified as their major cellular protein interactors. This review focuses on the various cellular functions of mammalian Argonaute proteins in conjunction with the different small RNA species that are known today.
诸如小干扰RNA（siRNA）、微小RNA（miRNA）和Piwi相互作用RNA（piRNA）等小调控RNA过去就已被发现，并且这些小分子具有关键调控功能这一点正变得越来越明显。小RNA存在于所有高等真核生物中，并在发育、应激反应或转座子沉默等多种细胞过程中发挥重要作用。在小调控RNA被发现后不久，AGO蛋白家族成员就被鉴定为它们主要的细胞蛋白相互作用因子。本综述聚焦于哺乳动物AGO蛋白与目前已知的不同小RNA种类相关的各种细胞功能。
