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它标记体谱系的前体，并在海葵中形成生殖细胞系是必需的。

marks precursors of somatic lineages and is required for germline formation in the sea anemone .

机构信息

Department of Neurosciences and Developmental Biology, Faculty of Life Sciences, University of Vienna, Djerassiplatz 1, 1030 Vienna, Austria.

Research platform SINCEREST, University of Vienna, Djerassiplatz 1, 1030 Vienna, Austria.

出版信息

Sci Adv. 2024 Aug 16;10(33):eado0424. doi: 10.1126/sciadv.ado0424.

DOI:10.1126/sciadv.ado0424
PMID:39151009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11328910/
Abstract

In animals, stem cell populations of varying potency facilitate regeneration and tissue homeostasis. Notably, germline stem cells in both vertebrates and invertebrates express highly conserved RNA binding proteins, such as , , and . In highly regenerative animals, these genes are also expressed in somatic stem cells, which led to the proposal that they had an ancestral role in all stem cells. In cnidarians, multi- and pluripotent interstitial stem cells have only been identified in hydrozoans. Therefore, it is currently unclear if cnidarian stem cell systems share a common evolutionary origin. We, therefore, aimed to characterize conserved stem cell marker genes in the sea anemone . Through transgenic reporter genes and single-cell transcriptomics, we identify cell populations expressing the germline-associated markers and in the soma and germline, and gene knockout shows that Nanos2 is indispensable for germline formation. This suggests that and genes have a conserved role in somatic and germline stem cells in cnidarians.

摘要

在动物中，具有不同潜能的干细胞群体促进了再生和组织稳态。值得注意的是，脊椎动物和无脊椎动物中的生殖干细胞都表达高度保守的 RNA 结合蛋白，如 、 和 。在高度再生的动物中，这些基因也在体干细胞中表达，这导致人们提出它们在所有干细胞中具有祖先作用。在刺胞动物中，多能和多能间质干细胞仅在水螅纲中被鉴定出来。因此，目前尚不清楚刺胞动物干细胞系统是否具有共同的进化起源。因此，我们旨在表征海葵 中的保守干细胞标记基因。通过转基因报告基因和单细胞转录组学，我们在体和生殖系中鉴定出表达生殖系相关标记 和 的细胞群体，基因敲除表明 Nanos2 对于生殖系的形成是不可或缺的。这表明 和 基因在刺胞动物的体干细胞和生殖干细胞中具有保守作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/238029e10dda/sciadv.ado0424-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/8eaa37fd5295/sciadv.ado0424-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/eeb467d98dc1/sciadv.ado0424-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/35a7b367a02e/sciadv.ado0424-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/a3d3e38575c8/sciadv.ado0424-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/238029e10dda/sciadv.ado0424-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/8eaa37fd5295/sciadv.ado0424-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/57c2bfba1b35/sciadv.ado0424-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/8be72a2a4b14/sciadv.ado0424-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/a6410ec6b933/sciadv.ado0424-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/eeb467d98dc1/sciadv.ado0424-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/35a7b367a02e/sciadv.ado0424-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/a3d3e38575c8/sciadv.ado0424-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/17b5/11328910/238029e10dda/sciadv.ado0424-f8.jpg

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