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Further evidence for leptin involvement in cartilage homeostases.

作者信息

Gualillo O

出版信息

Osteoarthritis Cartilage. 2007 Aug;15(8):857-60. doi: 10.1016/j.joca.2007.04.015. Epub 2007 Jun 8.

DOI:10.1016/j.joca.2007.04.015
PMID:17560812
Abstract
摘要

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1
Further evidence for leptin involvement in cartilage homeostases.瘦素参与软骨稳态的进一步证据。
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Evidence for a key role of leptin in osteoarthritis.瘦素在骨关节炎中起关键作用的证据。
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COMP does not directly modify the expression of genes involved in cartilage homeostasis in contrast to several other cartilage matrix proteins.与其他几种软骨基质蛋白不同,COMP不会直接改变参与软骨稳态的基因的表达。
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Obesity and osteoarthritis: is leptin the link?肥胖与骨关节炎:瘦素是其中的关联因素吗?
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Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism.晚期与轻度受累的骨关节炎软骨中瘦素及其受体亚型(Ob-Rb)mRNA的差异表达;对软骨代谢的影响。
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