Bellón Juan M, Rodríguez Marta, García-Honduvilla Natalio, Pascual Gemma, Buján Julia
Department of Surgery, Alcalá University, Ctra Madrid-Barcelona, Km 33.600, 28871 Alcalá de Henares, Madrid, Spain.
Am J Surg. 2007 Jul;194(1):68-74. doi: 10.1016/j.amjsurg.2006.11.016.
The aim of this study was to establish whether new prosthetic materials with absorbable components, designed to reduce the amount of foreign material in abdominal wall repair, offer advantages over the conventional polypropylene meshes.
Seven x 5 cm defects created in the anterior abdominal wall of New Zealand white rabbits were repaired by using a nonabsorbable polypropylene prosthesis (Surgipro; Tyco, Barcelona, Spain) or 1 of 2 partially absorbable prostheses available on the market (Vypro II and Ultrapro; Johnson & Johnson, St. Stevens-Woluwe, Belgium). At 14 and 90 days after surgery, tissue/prosthesis specimens were subjected to histological studies, biomechanical strength tests, and shrinkage evaluation.
At 90 days, the absorbable filaments of Vypro II had been completely reabsorbed, whereas Ultrapro only showed signs of biodegradation in a few zones. Host tissue infiltration and collagen I deposition in the 3 reticular meshes was optimal. Macrophage counts, mesh shrinkage, and biomechanical resistance values were similar.
Partially absorbable prostheses perform as well as the standard polypropylene mesh and have the benefit that less foreign material remains in the recipient, without compromising mechanical resistance.
本研究的目的是确定旨在减少腹壁修复中外来材料量的含可吸收成分的新型假体材料是否比传统聚丙烯网片具有优势。
在新西兰白兔的前腹壁制造7×5 cm的缺损，使用不可吸收的聚丙烯假体（Surgipro；泰科医疗，西班牙巴塞罗那）或市场上现有的2种部分可吸收假体之一（Vypro II和Ultrapro；强生公司，比利时圣史蒂文斯 - 伍卢韦）进行修复。在术后14天和90天，对组织/假体标本进行组织学研究、生物力学强度测试和收缩评估。
在90天时，Vypro II的可吸收细丝已完全吸收，而Ultrapro仅在少数区域显示出生物降解迹象。3种网状网片中宿主组织浸润和I型胶原沉积情况良好。巨噬细胞计数、网片收缩和生物力学阻力值相似。
部分可吸收假体的性能与标准聚丙烯网片相同，且优点是在受体中残留的外来材料较少，同时不影响机械阻力。
