瑞他莫林对金黄色葡萄球菌细胞中翻译及50S核糖体亚基形成的抑制作用。
Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells.
作者信息
Champney W Scott, Rodgers Ward K
机构信息
Department of Biochemistry and Molecular Biology, J. H. Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
出版信息
Antimicrob Agents Chemother. 2007 Sep;51(9):3385-7. doi: 10.1128/AAC.00475-07. Epub 2007 Jun 11.
Abstract
Retapamulin inhibited protein biosynthesis and cell viability in methicillin-sensitive and methicillin-resistant Staphylococcus aureus organisms. A specific inhibitory effect on 50S ribosomal subunit formation was also found. Pulse-chase labeling experiments confirmed the specific inhibition of 50S subunit biogenesis. Turnover of 23S rRNA was found, with no effect on 16S rRNA amounts.
摘要
瑞他莫林可抑制甲氧西林敏感和耐甲氧西林金黄色葡萄球菌的蛋白质生物合成及细胞活力。还发现其对50S核糖体亚基形成具有特异性抑制作用。脉冲追踪标记实验证实了对50S亚基生物合成的特异性抑制。研究发现23S rRNA有周转现象，而对16S rRNA的量无影响。
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