与其他药物相比，瑞他帕林对金黄色葡萄球菌和化脓性链球菌活性的单步和多步耐药性选择研究。
Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes.
作者信息
Kosowska-Shick Klaudia, Clark Catherine, Credito Kim, McGhee Pamela, Dewasse Bonifacio, Bogdanovich Tatiana, Appelbaum Peter C
机构信息
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
出版信息
Antimicrob Agents Chemother. 2006 Feb;50(2):765-9. doi: 10.1128/AAC.50.2.765-769.2006.
Abstract
Retapamulin had the lowest rate of spontaneous mutations by single-step passaging and the lowest parent and selected mutant MICs by multistep passaging among all drugs tested for all Staphylococcus aureus strains and three Streptococcus pyogenes strains which yielded resistant clones. Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance development in S. aureus.
摘要
在对所有金黄色葡萄球菌菌株和三株酿脓链球菌菌株进行测试的所有药物中，通过单步传代，瑞他帕林的自发突变率最低；通过多步传代，其亲本和筛选出的突变体的最低抑菌浓度（MIC）也最低，这三株酿脓链球菌菌株产生了耐药克隆。瑞他帕林在酿脓链球菌中产生耐药性的可能性较低，在金黄色葡萄球菌中耐药性发展缓慢且呈渐进性。
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