在微波辅助条件下，通过金（I）催化的串联氢胺化-氢芳基化反应，由芳香胺和炔烃合成取代的1,2-二氢喹啉和喹啉。
Synthesis of substituted 1,2-dihydroquinolines and quinolines from aromatic amines and alkynes by gold(I)-catalyzed tandem hydroamination-hydroarylation under microwave-assisted conditions.
作者信息
Liu Xin-Yuan, Ding Pan, Huang Jie-Sheng, Che Chi-Ming
机构信息
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, People's Republic of China.
出版信息
Org Lett. 2007 Jul 5;9(14):2645-8. doi: 10.1021/ol070814l. Epub 2007 Jun 12.
PMID:17564458
Abstract
A method to efficiently prepare substituted 1,2-dihydroquinolines and quinolines by Au(I)-catalyzed tandem hydroamination-hydroarylation under microwave irradiation was developed. This method requires short reaction time (10-70 min) and has a broad substrate scope.
摘要
开发了一种在微波辐射下通过金（I）催化的串联氢胺化-氢芳基化反应高效制备取代的1,2-二氢喹啉和喹啉的方法。该方法反应时间短（10-70分钟），底物范围广。
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