Voronov Polina, Przybylo Henry J, Jagannathan Narasimhan
Department of Anesthesiology, Children's Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Paediatr Anaesth. 2007 Jul;17(7):684-7. doi: 10.1111/j.1460-9592.2006.02182.x.
We present a case of a 29 months old previously healthy child who experienced apnea resulting in brain injury following a dose of acetaminophen and codeine 2 days after an uneventful anesthetic for tonsillectomy. A genetic polymorphism leading to ultra-rapid metabolism of codeine into morphine resulted in narcosis and apnea. This paper discusses the use of codeine for pain relief, obstructive sleep apnea, the alteration of the CYP2D6 gene and the resulting effect on drug metabolism.
我们报告一例29个月大的既往健康儿童，在扁桃体切除术后顺利麻醉2天后，服用一剂对乙酰氨基酚和可待因后出现呼吸暂停，导致脑损伤。一种导致可待因超快速代谢为吗啡的基因多态性导致了麻醉和呼吸暂停。本文讨论了可待因用于止痛、阻塞性睡眠呼吸暂停、CYP2D6基因改变及其对药物代谢的影响。
