Kida Yohei, Maeshima Etsuko, Furukawa Kanako, Ichikawa Tomohiro, Goda Mikako, Ichinose Masakazu
Third Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan.
Mod Rheumatol. 2007;17(3):262-4. doi: 10.1007/s10165-007-0579-6. Epub 2007 Jun 20.
A 53-year-old man was diagnosed with polymyositis (PM) in 1997 and treated with prednisolone. The subjective symptoms of pneumonitis were poor. However, the KL-6 values were elevated to 2230 IU/l in March 2001. Abdominal computer tomography findings revealed a pancreatic-tail tumor and multiple liver nodules, diagnosed as primary pancreatic adenocarcinoma with multiple liver metastasis. The stage of the pancreatic cancer was IV, and curative surgery of the tumor was not indicated. Chemotherapy and radiotherapy were administered for the liver metastasis. However, these therapies were ineffective against the tumors. The patient died on 12 September 2001. If a high level of KL-6 is found without the increasing activity of lung disease containing interstitial pneumonia in PM patients, examination for the internal malignancies including pancreatic cancer should be performed, although cases of PM with a significantly high level of KL-6 associated with pancreatic cancer are rare.
一名53岁男性于1997年被诊断为多发性肌炎（PM），并接受泼尼松龙治疗。肺炎的主观症状较轻。然而，2001年3月KL-6值升高至2230 IU/l。腹部计算机断层扫描结果显示胰尾肿瘤和多个肝结节，诊断为原发性胰腺腺癌伴多发肝转移。胰腺癌分期为IV期，不适合进行肿瘤根治性手术。对肝转移灶进行了化疗和放疗。然而，这些治疗对肿瘤无效。患者于2001年9月12日死亡。在PM患者中，如果在不伴有包括间质性肺炎在内的肺部疾病活动增加的情况下发现KL-6水平升高，应进行包括胰腺癌在内的内部恶性肿瘤检查，尽管与胰腺癌相关的KL-6水平显著升高的PM病例很少见。
