Tai Yin-Shan
Cereal Crops Research Unit, U.S. Department of Agriculture-Agricultural Research Service, Fargo, ND 58105-5677, USA.
Mol Biol Rep. 2008 Sep;35(3):337-43. doi: 10.1007/s11033-007-9091-5. Epub 2007 Jun 13.
RAR1 and SGT1 are required for development and disease resistance in plants. In many cases, RAR1 and SGT1 regulate the resistance (R)-gene-mediated defense signaling pathways. Lr21 is the first identified NBS-LRR-type R protein in wheat and is required for resistance to the leaf rust pathogen. The Lr21-mediated signaling pathways require the wheat homologs of RAR1, SGT1, and HSP90. However, the molecular mechanisms of the Lr21-mediated signaling networks remain unknown. Here I present the DNA and protein sequences of TaRAR1 and TaSGT1, and demonstrate for the first time a direct protein-protein interaction between them.
RAR1和SGT1是植物发育和抗病性所必需的。在许多情况下，RAR1和SGT1调节抗性（R）基因介导的防御信号通路。Lr21是在小麦中首次鉴定出的NBS-LRR型R蛋白，是抗叶锈病病原体所必需的。Lr21介导的信号通路需要RAR1、SGT1和HSP90的小麦同源物。然而，Lr21介导的信号网络的分子机制仍然未知。在这里，我展示了TaRAR1和TaSGT1的DNA和蛋白质序列，并首次证明了它们之间直接的蛋白质-蛋白质相互作用。
