Chagnaud J L, Bourême D, Faiderbe S, Geffard M
Laboratoire d'Immunologie et de Pathologie (CJF 88-13 INSERM), Université de Bordeaux II, France.
Cancer Lett. 1991 Dec 1;60(3):229-35. doi: 10.1016/0304-3835(91)90118-2.
Many authors have previously described that several types of human cancer were associated with elevated levels of IgA and IgA-containing immune complexes. We have recently identified and characterized IgA directed against a "benzo[a]pyrene-like' antigen in sera of patients with mammary tumors. Circulating immune complexes from these sera were precipitated and analysed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. A 18-20-kDa protein was found closely associated with high levels of anti-'benzo[a]pyrene-like' IgA in sera of patients having a proliferative pathology.
许多作者先前曾描述过，几种类型的人类癌症与IgA水平升高以及含IgA的免疫复合物有关。我们最近在乳腺肿瘤患者的血清中鉴定并表征了针对“苯并[a]芘样”抗原的IgA。这些血清中的循环免疫复合物经沉淀后，通过十二烷基硫酸钠-聚丙烯酰胺凝胶电泳进行分析。在患有增殖性病变的患者血清中，发现一种18 - 20 kDa的蛋白质与高水平的抗“苯并[a]芘样”IgA密切相关。
