Kim Jeong Hwan, Rhee Poong-Lyul, Lee Jun Haeng, Lee Hyuk, Choi Yong Sung, Son Hee Jung, Kim Jae J, Rhee Jong Chul
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea.
J Gastroenterol Hepatol. 2007 Jun;22(6):908-12. doi: 10.1111/j.1440-1746.2006.04448.x.
Barrett's esophagus (BE) is diagnosed when specialized intestinal metaplasia (SIM) is detected histologically in endoscopically suspected columnar-lined esophagus (CLE). It is a premalignant condition and plays a pivotal role in the development of esophageal adenocarcinoma. It has traditionally been believed to affect Asians less frequently. The aim of this study was to determine the prevalence of BE and possible associated risk factors in Korea.
A retrospective analysis of 70 103 patients who had undergone their first upper endoscopies was performed using computerized medical records. Of these, 696 (1%) patients had suspected CLE. After screening by telephone, 480 were enrolled. The clinical and endoscopic characteristics of histologically identifiable BE and endoscopically suspected CLE not confirmed by biopsy (suspected CLE without SIM) were investigated.
Barrett's esophagus was present in 151 patients (0.22%) with a mean age of 53.8 +/- 10.9 years. BE was more commonly found in men. BE was associated with a set of features distinct from suspected CLE without SIM; older age, greater predominance of male sex, more frequent smoking history, and more frequent acid regurgitation symptom.
Barrett's esophagus remains less common in Korea than in Western countries. Old age, male sex, smoking, and acid regurgitation symptom were significant risk factors.
当在内镜检查怀疑为柱状上皮化生食管（CLE）的组织学检查中发现特殊肠化生（SIM）时，即可诊断为巴雷特食管（BE）。它是一种癌前病变，在食管腺癌的发生发展中起关键作用。传统上认为亚洲人受其影响的频率较低。本研究的目的是确定韩国BE的患病率及可能的相关危险因素。
利用计算机化病历对70103例首次接受上消化道内镜检查的患者进行回顾性分析。其中，696例（1%）患者怀疑有CLE。经电话筛查后，纳入480例。对组织学可确诊的BE以及经活检未证实的内镜怀疑CLE（无SIM的疑似CLE）的临床和内镜特征进行了研究。
151例患者（0.22%）存在巴雷特食管，平均年龄为53.8±10.9岁。BE在男性中更为常见。BE与一组不同于无SIM的疑似CLE的特征相关；年龄较大、男性占比更高、吸烟史更频繁以及反酸症状更频繁。
在韩国，巴雷特食管仍然比西方国家少见。老年、男性、吸烟和反酸症状是重要的危险因素。
