Eralp Levant, Ozkan Korhan, Kocaoglu Mehmet, Aktas Samil, Zihni Mutlu, Türker Mehmet, Ozkan Feyza Unlu
Department of Orthopaedics and Traumatology, Medical Faculty of Istanbul, University of Istanbul, Istanbul, Turkey.
Adv Ther. 2007 Mar-Apr;24(2):326-32. doi: 10.1007/BF02849901.
Investigators in the present study explored the effects of hyperbaric oxygen (HBO) therapy on distraction osteogenesis in a rabbit limb-lengthening model. HBO treatment was provided to participants in a small animal pressure chamber once a day during the latent period of distraction osteogenesis at 2.5 absolute atmospheres of pressure. Bone mineral density measurements were obtained through torsional testing. The control group received no HBO treatment. Animals were killed 8 wk postoperatively for biomechanical testing. There was a statistically significant increase in bone mineral density in the HBO group compared with that in the non-HBO group, but no statistically significant differences were observed between biomechanical parameters of the 2 groups. The investigators suggest that these results must be further studied through histologic examination to determine the stepwise effects of HBO during and after collagen synthesis.
本研究的调查人员在兔肢体延长模型中探究了高压氧（HBO）疗法对牵张成骨的影响。在牵张成骨的潜伏期，每天在小动物压力舱中以2.5绝对大气压对参与者进行一次HBO治疗。通过扭转试验获得骨矿物质密度测量值。对照组未接受HBO治疗。术后8周处死动物进行生物力学测试。与非HBO组相比，HBO组的骨矿物质密度有统计学显著增加，但两组的生物力学参数之间未观察到统计学显著差异。研究人员建议，必须通过组织学检查进一步研究这些结果，以确定HBO在胶原蛋白合成期间及之后的逐步作用。
