Ueng S W, Lee S S, Lin S S, Wang C R, Liu S J, Yang H F, Tai C L, Shih C H
Department of Orthopaedic Surgery of Chang Gung Memorial Hospital, Keelung, Taiwan.
J Trauma. 1998 Apr;44(4):676-81. doi: 10.1097/00005373-199804000-00020.
We investigated the effect of intermittent hyperbaric oxygen (HBO) therapy on the bone healing of tibial lengthening in rabbits. Twelve male rabbits were divided into two groups of six animals each. The first group went through 2.5 atmospheres absolute of hyperbaric oxygenation for 2 hours daily, and the second group did not go through hyperbaric oxygenation. Each animal's right tibia was lengthened 5 mm using an uniplanar lengthening device. Bone mineral density (BMD) study was performed for all of the animals at 1 day before operation and at 3, 4, 5, and 6 weeks after operation. All of the animals were killed at 6 weeks postoperatively for biomechanical testing. Using the preoperative BMD as an internal control, we found that the BMD of the HBO group was increased significantly compared with the non HBO group. The mean %BMD at 3, 4, 5, and 6 weeks were 69.5%, 80.1%, 87.8%, and 96.9%, respectively, in HBO group, whereas the mean %BMD were 51.6%, 67.7%, 70.5%, and 79.2%, respectively, in non-HBO group (two tailed t test, p < 0.01, p < 0.01, p < 0.01, and p < 0.01 at 3, 4, 5, and 6 weeks, respectively). Using the contralateral nonoperated tibia as an internal control, we found that torsional strength of lengthened tibia of the HBO group was increased significantly compared with the non-HBO group. The mean percent of maximal torque was 88.6% in HBO group at 6 weeks, whereas the mean percent of maximal torque was 76.0% in non-HBO group (two-tailed t test, p < 0.01). The results of this study suggest that the bone healing of tibial lengthening is enhanced by intermittent hyperbaric oxygen therapy.
我们研究了间歇性高压氧（HBO）疗法对兔胫骨延长术后骨愈合的影响。将12只雄性兔分为两组，每组6只。第一组每天接受2.5绝对大气压的高压氧治疗2小时，第二组不接受高压氧治疗。使用单平面延长装置将每只动物的右胫骨延长5毫米。在术前1天以及术后3、4、5和6周对所有动物进行骨密度（BMD）研究。术后6周处死所有动物进行生物力学测试。以术前BMD作为内部对照，我们发现HBO组的BMD与非HBO组相比显著增加。HBO组在3、4、5和6周时的平均BMD百分比分别为69.5%、80.1%、87.8%和96.9%，而非HBO组的平均BMD百分比分别为51.6%、67.7%、70.5%和79.2%（双尾t检验，在3、4、5和6周时p值分别<0.01、<0.01、<0.01和<0.01）。以对侧未手术的胫骨作为内部对照，我们发现HBO组延长胫骨的扭转强度与非HBO组相比显著增加。HBO组在6周时最大扭矩的平均百分比为88.6%，而非HBO组为76.0%（双尾t检验，p<0.01）。本研究结果表明，间歇性高压氧疗法可促进胫骨延长术后的骨愈合。
