Suer Berkay Tolga, Ortakoglu Kerim, Gunaydin Yilmaz, Sencimen Metin, Mutlu Ibrahim, Dogan Necdet, Kaya Ayper
From the *Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy (GMMA), Haydarpasa Teaching Hospital; †Service of Dental Medicine, Medicana Hospital, Istanbul; §Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy (GMMA), Etlik; ∥Department of Dental Medicine, Tatvan Military Hospital, Tatvan; ‡Private Practice, Ankara; and ¶Kasimpasa Military Hospital, Kasimpasa, Istanbul, Turkey.
J Craniofac Surg. 2014 Sep;25(5):1740-5. doi: 10.1097/SCS.0000000000000996.
The purpose of this study was to investigate the effect of hyperbaric oxygen (HBO) therapy on de novo bone formation during periosteal distraction (PD).
Periosteal distraction was performed in 24 mature male New Zealand rabbits using a custom-designed device placed on the lateral surface of the mandibular corpus. Twelve rabbits (group H) were given adjunctive HBO treatment, whereas 12 rabbits (group N) were kept in a normal environment (normobaric oxygen). After a 7-day latency period, the same distraction protocol was applied to both groups. However, the rabbits in group H were treated with pure oxygen at 2.4 atm absolute for 25 times. Both groups were further divided into 2 subgroups and killed after consolidation periods of 4 and 8 weeks. Photodensitometric and histologic analyses were performed to evaluate the newly formed bone.
There was no significant difference between the 4-week consolidated HBO group and the 8-week consolidated normobaric oxygen subgroup (P = 0.229). Moreover, there was better bone formation in the 8-week HBO group than in the 8-week control group.
The results of this study indicate that PD with HBO could be used to increase the quality and the quantity of the bone newly formed by PD.
本研究旨在探讨高压氧（HBO）治疗对骨膜牵张（PD）过程中新生骨形成的影响。
使用定制设计的装置置于24只成年雄性新西兰兔下颌骨体外侧表面进行骨膜牵张。12只兔子（H组）接受辅助HBO治疗，而12只兔子（N组）置于正常环境（常压氧）中。经过7天的潜伏期后，两组采用相同的牵张方案。然而，H组兔子在绝对压力2.4个大气压下接受纯氧治疗25次。两组进一步分为2个亚组，并在4周和8周的巩固期后处死。进行光密度分析和组织学分析以评估新形成的骨。
4周巩固的HBO组与8周巩固的常压氧亚组之间无显著差异（P = 0.229）。此外，8周HBO组的骨形成比8周对照组更好。
本研究结果表明，PD联合HBO可用于提高PD新形成骨的质量和数量。
