由真菌菌株哈茨木霉F000527产生的哈茨木霉A和B及其对肿瘤细胞系的细胞毒性。
Harzianums A and B produced by a fungal strain, Hypocrea sp. F000527, and their cytotoxicity against tumor cell lines.
作者信息
Jin H-Z, Lee J-H, Zhang W-D, Lee H-B, Hong Y-S, Kim Y-H, Lee J-J
机构信息
School of Pharmacy, Shanghai, Jiao Tong University, Shanghai 200240, China.
出版信息
J Asian Nat Prod Res. 2007 Apr-Aug;9(3-5):203-7. doi: 10.1080/10286020500531977.
A new compound, harzianum B (1), was isolated from the culture broth of a fungal strain, Hypocrea sp. F000527, together with a known trichothecene, harzianum A (2). Its structure was determined by spectroscopic analyses including HRFAB-MS and various (1)H NMR and (13)C NMR spectral data. Harzianum B (1) was characterised as (E,Z,E)-2', 4', 6'-octatriendioic acid esterified on the 4beta-hydroxyl group of trichodermol. Harzianums A (2) and B (1) showed cytotoxicity against several human cancer cell lines.
从真菌菌株哈茨木霉属Hypocrea sp. F000527的培养液中分离出一种新化合物哈茨木霉B（1），同时还分离出一种已知的单端孢霉烯族毒素哈茨木霉A（2）。通过包括高分辨快原子轰击质谱（HRFAB-MS）以及各种氢核磁共振（1H NMR）和碳核磁共振（13C NMR）光谱数据在内的光谱分析确定了其结构。哈茨木霉B（1）的特征为在木霉醇4β-羟基上酯化的（E,Z,E）-2', 4', 6'-辛三烯二酸。哈茨木霉A（2）和B（1）对几种人类癌细胞系显示出细胞毒性。
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